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抑制剂 & 化合物

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重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T76393 Amyloid 17-42

Amyloid 17-42 (Aβ(17-42)),作为阿尔茨海默病中弥漫性斑块与唐氏综合症小脑前区的主要淀粉样蛋白成分,源于淀粉样蛋白前体蛋白(APP)经α与γ分泌酶的裂解作用。此外,Amyloid 17-42能通过Fas样/caspase-8途径促使神经细胞发生凋亡。

化合物

Amyloid 17-42
Cat.No: T76393
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPK-00276 TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)

ZTNFR9,DR5TRICK2B,DR5,TRAIL receptor 2,TRICKB,TNFRSF10B,TRIC...

Human HEK293 Cells
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
TMPK-00277 TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)

TRAIL R2,TNFRSF10B,TRICK2,KILLER,DR5,TRAIL receptor 2,Fa...

Human HEK293 Cells
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
TMPJ-01256 Caspase-10 Protein, Human, Recombinant (His)

CASP10,FAS-Associated Death Domain Protein...

Human E. coli
Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human ca...
TMPY-02578 DKKL1 Protein, Human, Recombinant (hFc)

SGY,dickkopf-like 1,CT34,SGY1,SGY-1

Human HEK293 Cells
Dickkopf-like 1 (DKKL1) or soggy 1, is a glycoprotein unique to mammals that is expressed primarily in developing spermatocytes and localized in the acrosome of mature sperm. It is also expressed in the trophectoderm / placental lineage. This glycoprotein is secreted by postmeiotic male germ cells. DKKL1 is a member of the Dickkopf (DKK) family, a group of proteins that are characterized as secreted antagonists of Wnt signal transduction proteins. In mammals, embryos lacking DKKL1 protein develo...

重组蛋白

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00276
Species: Human
Expression System: HEK293 Cells
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00277
Species: Human
Expression System: HEK293 Cells
Caspase-10 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01256
Species: Human
Expression System: E. coli
DKKL1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-02578
Species: Human
Expression System: HEK293 Cells
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